serous adenocarcinoma


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  • Clinical

    • old, postmenopausal
    • invasive

  • Gross

    • small uterus
    • exophytic
    • papillary

  • Histology

    • architecture
      • papillary, solid with slit-like spaces
      • delicate cores and tufts
      • shaggy or scalloped gland lumen
    • cytology
      • high grade nuclei
      • hobnailing
    • psammoma bodies

  • Stains

    • strong diffuse p53
      • vs low grade endometrioid
    • strong diffuse p16
    • Ki-67 high
    • ER/PR focal
      • vs endometrioid is diffuse strong
    • other
      • pancytokeratin+, EMA+, CA125+, Ber EP4+, B72.3+, CK7+, vimentin+, CK20-, CEA focal/weak

  • Other

    • negative for PTEN and mismatch repair gene mutation
      • vs endometrioid which has those
    • negative/uncommon WT1
      • vs ovarian/tubal/peritoneal serous (common)
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