sclerosing epithelioid fibrosarcoma


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  • Clinical

    • median age 45
    • site: lower extremities, girdles, trunk, upper extremities, head and neck
    • size: 2-22cm
    • adverse prognostic factors: proximal site, larger size, male, local recurrence, metastasis

  • Histology

    • sclerotic
    • epithelioid cells
      • cords, nests, strands, acini
      • clear-eosinophilic cytoplasm
      • low mitosis
    • collagen
      • bands, laces

  • Stains

    • Cd34+
    • negative for CD34, CD68, HMB45, desmin, GFAP, p53
    • weak/rare EMA, S100, CK
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