salivary duct carcinoma


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  • Clinical

    • male predominance

  • Histology

    • resembles breast ductal carcinoma
    • roman bridges
    • often oncocytic cytoplasm
    • perineural, perivascular invasion
    • node mets

  • Stains

    • androgen receptor (90%)
    • GCDFP15 (80%)
    • EGFR (50%)
    • mimicks prostate: PSA (50%), PAP (20%)
    • mimicks breast: PR (6%), ER (1%), HER2 (some, high grade)

  • Ddx

    • SCC
    • adenocarcinoma (NOS, metastatic)
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