progressive transformation of germinal centers
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Clinical- children, young adults
- male > female
- isolated enlarged node, incidental finding
Histology- focal nodule(s) of irregular/fragmented germinal centers
- expanded mantle zone
- lack of atypia
- background follicular hyperplasia
Stains- nodules are B (CD20+) and mantle (Bcl2+) cells
Ddx
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