progressive transformation of germinal centers


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  • Clinical

    • children, young adults
    • male > female
    • isolated enlarged node, incidental finding

  • Histology

    • focal nodule(s) of irregular/fragmented germinal centers
      • expanded mantle zone
      • lack of atypia
    • background follicular hyperplasia

  • Stains

    • nodules are B (CD20+) and mantle (Bcl2+) cells

  • Ddx

    		•