plexiform fibrohistiocytic tumor


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  • Clinical

    • site: upper extremities (65%), lower extremities (27%)

  • Histology

    • architecture: multinodular or plexiform cell clusters
    • 3 cell types: histiocyte-like, spindle, multinucleated giant cells
    • subtypes
      • fibrohistiocytic: nodules of histiocyte-like cells
      • fibroblastic: elongated clusters and short fascicles of fibroblast-like cells
      • mixed: both of the above

  • Stains

    • positive: vimentin, CD68, SMA
    • CD68 in histiocyte-like cells and giant cells
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