mucinous adenocarcinoma


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  • Histology

    • at least some cells contain intracytoplasmic mucin

  • Variants

    • endocervical variant
      • 70% of all cervical adenocarcinoma
      • endocervical-like glands
        • well-moderate differentiated
        • can have lumen papilla, cribriforming
        • rarely microglandular or microcystic
        • stratification
        • atypia, mitosis
      • desmoplastic stroma
    • intestinal variant
      • resembles large intestine adenocarcinoma
      • goblet cells
      • less commonly endocrine and paneth cells
    • signet ring cell variant
    • minimal deviation variant
      • haphazard, infiltrative, normal-appearing endocervical glands
      • occasional nuclear atypia, mitosis, claw-shaped glands, desmoplasia
      • frequent vascular and perineural invasion
      • 40% transmural, parametrial or myometrial spread
      • STK11 mutation
    • villoglandular variant
      • villoglandular fronds
      • columnar cell lining

  • Stains

    • mucin+
    		•