Apps
Surgpath
→
heme
→
lymph node
mono
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Clinical
teen/young adult
fever, sore throat, cervical lymphadenopathy
EBV
Histology
paracortical hyperplasia
lymphoid cells with varying maturity
atypical immunoblasts
mitosis, +/- necrosis
Stains
EBV+
immunoblasts: CD20+, CD10-, CD15-
Ddx
Hodgkin lymphoma
CD30+, CD15+
DLBCL
older pt
peripheral Tcell lymphoma
CMV
EBV negative, CMV+
HIV
follicular hyperplasia