melanoma


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  • Histology

    • broad, can involve dome of dermal papillae
    • lots of non-nested melanocytes, elongated/bizarre nests
    • can have epidermal spread (buckshot scatter)
    • lack maturation, dispersion
    • has deep mitosis and pigmentation

  • Variants

  • Stains

    • HMB45 has strong base staining
    • MIB1 stains deep nuclei

  • Clark levels

    • I: epidermis, in situ
    • II: papillary dermis
    • III: papillary-reticular dermis interface
    • IV: reticular dermis
    • V: fat
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