macrocytic anemia


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  • Megaloblastic

    • B12, folate
    • EtOH, drugs (hydroxyurea, chemo, HAART)
    • congenital dyserythropoietic anemia

  • Marrow

    • diamond-blackfan: hematogones, erythroid aplasia
    • MDS
    • siderblastic anemia
      • dimorphic nml + microcytic hypochromic cells
      • marrow erythroid hyperplasia
      • ring sideroblasts
    • chemo
    • infiltration, fibrosis

  • Other

    • liver disease -> portal HTN -> splenomegaly -> hemolysis, macrocytosis
    • hypothyroid
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