leiomyosarcoma


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  • Clinical

    • age > 30, median 50

  • Gross

    • 8 cm average
    • margin poorly defined
    • fleshy
    • hemorrhage, necrosis

  • Histology

    • spindle cells
    • mitosis > 15 per 10hpf
    • LVSI in 25%
    • others
      • prominent tumor necrosis
      • giant cells

  • Variants

    • epithelioid leiomyosarcoma
      • more rounded cells
    • myxoid leiomyosarcoma
      • myxoid material separating neoplastic cells

  • Ddx

    • leuprolide induced cell necrosis
    		•