large cell neuroendocrine carcinoma


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  • Clinical

    • smoker predominance
    • peripheral

  • Histology

    • architecture
      • nesting
      • trabecular
      • rosettes
      • perilobular palisading
    • nuclei larger than 3x lymphocyte
    • prominent nucleoli
    • mitosis
    • necrosis
    • can have components of other carcinoma

  • Stains

    • chromogranin, synaptophysin, CD56+
    • TTF1+/- (50%)

  • Ddx

    • atypical carcinoid (less mitosis, necrosis)
    • poorly differentiated SCC (has at least focal squamous diff)
    • solid adenocarcinoma (has mucin)
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