inflammatory myofibroblastic tumor


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  • Clinical

    • age: children, young adult
    • site: abdominal, pelvis, retroperitoneum, lung, mediastinum, head/neck
    • associations: HHV8, Wilms tumor treatment
    • benign or malignant (inflammatory fibrosarcoma)

  • Histology

    • myofibroblasts: spindle, plump or ganglion-like
    • inflammation: lymphs, plasma cells, eos
    • different patterns
      • loose edematous, has eosinophils
      • compact fascicular
      • scar-like, can have calcifications, osseous metaplasia

  • Stains

    • vimentin+
    • focal to diffuse actin
    • ALK+ in 50%
    • can have focal CK
    • myogenin, S100 negative
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