infantile fibrosarcoma


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  • Clinical

    • age: infants, young children
    • site: extremities, trunk, head and neck. Rarely mesentery or retroperitoneal
    • prognosis: rarely metastasize, better outcome than adult fibrosarcoma

  • Histology

    • poorly circumscribed, infiltrative
    • herringbone fascicles, densely cellular
    • ovoid and spindle cells
    • necrosis, hemorrhage, calcifications

  • Stains

    • vimentin+
    • variable for NSE, actin
    • usually negative for desmin, S100, CD34

  • Molecular

    • ETV6/NTRK3 fusion, t(12;15)(p13;q26)
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