histiocytic sarcoma


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  • Clinical

    • mass +/- systemic sx
    • poor prognosis

  • Morphology

    • large pink cells with lots of cytoplasm
    • dyscohesive

  • Stains

    • positive: histiocytic (CD68, 163, lysozyme)
    • negative:
      • LCH (CD1a, langerin)
      • FDC (CD21, 35)
      • myeloid (13, 33, MPO)
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