hemolytic anemia


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  • Intrinsic

    • hemoglobinopathy
    • PNH
    • membrane defects
    • enzyme defects: PK (molecular), G6PD
    • oxidant drugs

  • Antibody mediated

    • HTR, HDFN
    • autoantibodies: warm, cold, PCH

  • Hostile environment

    • MAHA: TTP/HUS, DIC, malig HTN, HELLP, eclampsia
    • mechanical valves
    • vasculitis
    • drugs, chemicals, venom, burn, radiation

  • Infections

    • malaria
    • bartonella
    • clostridium
    • babesia

  • Other

    • liver dz or splenomegaly -> hemolysis, macrocytosis
    • vasulitis
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