follicular dendritic cell sarcoma


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  • Clinical

    • some association with Castleman disease
    • site: node (most common), oral, GI, skin/soft tissue, mediastinum, liver, spleen

  • Morphology

    • patterns: fascicles, whirls, sheets, nodules
    • cytology: spindle, ovoid, pink cells with indistinct borders
    • background lymphs

  • Stains

    • pos: FDC (CD21, 23, 35), clusterin
    • neg: CD1a, lysozyme, MPO, CD34
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