diffuse type giant cell tumor


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  • Names

    • diffuse type giant cell tumor
    • pigmented villonodular synovitis
    • pigmented villonodular tenosynovitis

  • Clinical

    • age < 40
    • site: knee (75%), hip (15%), ankle, elbow, shoulder
    • locally aggressive

  • Histology

    • architecture: sheets, areas of high cellularity, infiltrative
    • mitosis readily identified, can be over 5 per 10 HPF
    • can have clefts, pseudoalveolar or pseudoglandular spaces
    • multinucleated giant cells
    • mononuclear cells
    • foamy macrophages

  • Stains

    • giant cells: CD68, CD45
    • mononuclear cells: CD68
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