dermatopathic lymphadenitis


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  • Clinical

    • chronic skin disease

  • Histology

    • nodular or diffuse paracortical hyperplasia
    • melanocytes
    • interdigitating dendritic cells
    • Langerhans cells

  • Stains

    • lymphocytes predominantly CD4+
    • Langerhans cells: S100+, CD1a+
    • interdigitating cells: S100+, CD1a-
    • histiocytes: CD68+, CD163+

  • Molecular

    • polyclonal T cells by TCR gene

  • Ddx

    • mycosis fungoides
      • monoclonal TCR gene
    • Langerhans cell histiocytosis
      • sinus histiocytosis with Langerhans cells, eosinophils, PMNs, plasma cells
    • nonspecific paracortical hyperplasia
      • less langerhans cells and dendritic cells
      • no melanocytes
    		•