congenital mesoblastic nephroma


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  • Clinical

    • 2% of pediatric renal tumors
    • congenital, dx in first year of life

  • Histology

    • classic type (like fibromatosis)
      • fascicles, entrapped renal parenchyma
      • cytology: spindled, low grade, few mitosis
    • cellular type (like fibrosarcoma)
      • sheet-like
      • cytology: small round blue cells, lots of mitosis, necrosis
    • mixed

  • Stains

    • vimentin+, actin+
    • CD34-, desmin-

  • Molecular

    • cellular type has ETV6-NTRK3 fusion
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