clear cell RCC


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  • Clinical

    • syndromes
      • VHL (3p25)
      • constitutional chromosome 3 translocation

  • Histology

    • architecture: solid, alveolar, acinar
    • clear cells
    • delicate vascular network

  • Stains

    • CD10+ (83%)
    • CD117- (1%)

  • Grading

    • 1: dark nuclei
    • 2: open chromatin
    • 3: prominent nucleoli
    • 4: ugly/pleomorphic nuclei

  • Molecular

    • VHL mutation leading to HIF activation
    • 3p deletion
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