choriocarcinoma


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  • Clinical

    • uterus
      • molar pregnancy (50%)
      • abortion (25%)
      • normal gestation (22%)
      • ectopic pregnancy (3%)

  • Histology

    • prominent hemorrhage, necrosis, and vascular invasion
    • tumor cells are at periphery of hemorrhage
    • biphasic atypical trophoblasts without villi
      • syncytiotrophoblasts (syncytial clusters)
      • cytotrophoblasts and intermediate trophoblasts (single cells)

  • Stains

    • CK+
    • syncytiotrophoblast: strong hCG, weak hPL
    • intermediate trophoblast: weak hCG, strong hPL

  • Ddx

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