celiac disease

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  • Clinical

    • associations: HLADQ2, HLADQ8
    • best antibody: anti endomysial
    • diarrhea, iron deficiency anemia (older adults)
  • Histology

    • location: proximal > distal small bowel, can be patchy
    • villus blunting, atrophy
    • intraepithelial lymphocytes (in tips of villi early stages)
    • enterocyte: cuboidal, loss of basal nuclear polarity, cytoplasmic vacuoles
    • other: crypt hyperplasia, thickened BM, reduced goblet cells, LP inflammation