carcinosarcoma


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  • Clinical

    • old
    • vaginal bleeding
    • polypoid mass through cervix

  • Gross

    • polypoid mass fills entire endometrial cavity
    • often protrude through cervical os

  • Histology

    • Biphasic
      • epithelial and stromal elements
      • intimately admixed
    • Epithelial component
      • common serous, endometrioid
    • Stromal component
      • homologous
        • spindle cell
        • pleomorphic
      • heterologous
        • rhabdomyosarcoma
        • chondrosarcoma

  • Stains

    • CK stains epithelial element
    • vimentin stains mesenchymal elements
    • p53 stains both
    • heterologous elements
      • desmin: rhabdo
      • S100: cartilage

  • Ddx

    • endometrioid adenocarcinoma with spindle cell elements (low grade)
    • undifferentiated carcinoma adjacent to well differentiated endometrioid tumor (two elements separate not admixed)
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