angiomyxoma


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  • Clinical

    • site: pelvic, perineal
    • prognosis: deep aggressive angiomyxoma has 30% recurrence

  • Histology

    • hyalinized vessels
    • spindle and stellate cells
    • myxoid stroma
    • entrapped local structures

  • Stains

    • positive: vimentin, ER/PR, desmin
    • variable: actin, CD34
    • negative: S100

  • Molecular

    • 12q13-15, HMG1C (HMGA2)
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