alveolar rhabdomyosarcoma


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  • Clinical

    • site: commonly in extremities. Also paraspinal, perineal, paranasal

  • Histology

    • cytology: small round blue cells
    • subtypes
      • typical: nests with fibrovascular septa
      • solid: sheets
      • mixed embryonal/alveolar

  • Stains

    • positive: myogenin

  • Molecular

    • t(2;13) = PAX3-FOXO1A
    • t(1;13) = PAX7-FOXO1A
    • FOXO1A 13q14
    • PAX3 2q36
    • PAX7 1p36
    		•