adult fibrosarcoma


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  • Clinical

    • site: deep soft tissues. Rarely visceral or retroperitoneal.
    • metastasize to lungs, bones

  • Histology

    • herringbone fascicles
    • spindle cells, high NC ratio, hyperchromasia
    • mitosis
    • stroma: variable collagen, hyaline, myxoid, osteochondroid metaplasia
    • aggressive features:
      • high grade
      • high cellularity
      • minimal collagen
      • mitosis > 20 per 10hpf
      • necrosis

  • Stains

    • pos: vimentin
    • SMA (9%, focal)
    • CD34 (8%, background DFSP or SFT)

  • Ddx

    		•