adenoid cystic carcinoma


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  • Clinical

    • most common submandibular gland malignancy
    • painful (perineural invasion common)
    • occasionally frozen section of facial nerve for perineural invasion

  • Histology

    • Architecture
      • cribriform (50%)
      • tubular (30%)
      • solid (20%)
    • stroma
      • eosinophilic
      • hyalinized
      • collagenous
    • perineural invasion (50%)

  • Ddx

    • PLGA (not cribriform)
    • basaloid SCC
    • epithelial myoepithelial carcinoma (not cribriform)

  • Associations

    • 6q translocation
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