adenocarcinoma


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  • Clinical

    • age: 60-70s
    • risk factors: genetic, gallstones, porcelain gallbladder, abnormal choledochopancreatic junction

  • Types

    • biliary type adenocarcinoma
      • tubular glands
      • cuboidal to tall columnar lining
    • intestinal type adenocarcinoma
      • type 1: resembles colonic adenocarcinoma
        • tubular glands
        • pseudostratified columnar lining
        • ovoid to elongated nuclei
      • type 2: predominantly goblet cells
      • stains: CDX2, MUC2, CEA, CK20
    • foveolar type adenocarcinoma
      • tall columnar cells
      • basal nuclei
      • abundant mucin cytoplasm
      • stains: MUC5A
    • mucinous adenocarcinoma
      • > 50% tumors extracellular mucin by convention
      • stains: CK, CEA
      • ddx: mucocele
    • signet ring carcinoma
    • clear cell adenocarcinoma
    • hepatoid adenocarcinoma
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