Whipple disease


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  • Clinical

    • male > female (8:1)
    • age: 40-50s
    • location: postbulbar duodenum, jejunum
    • diarrhea, wt loss

  • Histology

    • blunted villi
    • macrophages and dilated lacteals in lamina propria

  • Stains

    • PASD+ bacterial inclusions in macrophages
    		•