Whipple disease


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  • Clinical

    • Tropheryma whipplei
    • middle aged european males
    • migratory arthralgia, GI symptoms, weight loss

  • Histology

    • sinus histiocytosis
    • granulomas, non-necrotizing

  • Stains

    • PAS stains histiocytes (except in early disease)
    • T. whipplei

  • Ddx

    		•