T PLL


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  • Names

    • T cell prolymphocytic leukemia

  • Clinical

    • median age 65
    • organomegaly, generalized lymphadenopathy, skin involvement in 20%
    • lymphocytosis, anemia, thrombocytopenia

  • Morphology

    • T prolymphocytes (small-medium lymphoid cells)
    • prominent nucleolus
    • less common variants: small cells w/o nucleoli, cerebriform nuclei

  • Stains

    • positive: CD2, CD3, CD7, CD52
    • negative: TdT, CD1a
    • 25% coexpress CD4 and CD8
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