SCC



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  • Clinical

    • > 90% smoker
    • central location (bronchi)

  • Histology

    • squamous differentiation (at least focal)
    • keratin pearls
    • variants
      • papillary: exophytic growth
      • clear cell: clear cytoplasm
      • small cell: poorly differentiated
      • basaloid: peripheral palisading

  • Stains

    • high MW CK+
    • CK5/6+
    • CEA+

  • Molecular

    • near diploid or hyperdiploid
    • 3q telomere amplification
      • 3q24-qter
      • PIK3CA gene
    • 3p del
    • EGFR (84% of SCC)
    • p53
    • negative/rare for
      • KRAS
      • HER2/neu

  • Ddx

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