Merkel cell carcinoma


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  • Clinical

    • red nodule or plaque
    • 80% association with polyoma virus
    • bad prognosis

  • Histology

    • dermal diffuse
    • clusters, rosettes, cords

  • Stains

    • positive: CD56, synaptophysin, chromogranin, NSE, EMA
    • negative: S100, CD45, CK5-6, TTF, CEA
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