Kaposi sarcoma
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Clinical- HHV8
- clinical forms
- classic indolent: elderly men of mediterranean/east europe, lower legs
- endemic african: middle-aged HIV-negative adults and children, extremities
- iatrogenic: trasplant pts, lower legs
- AIDS: face, genitalia, lower legs, visceral involvement
Histology- patch stage: vascular proliferation
- plaque stage: additional inflammation, extravasated RBCs
- nodular stage: nodules and fascicles of spindle cells, slits with RBCs, hyaline globules
Stains- positive: HHV8, CD34, CD31
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