HCL


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  • Clinical

    • middle aged to elderly
    • male predominance (5:1)
    • site:marrow, spleen, a small amound in blood

  • Morphology

    • hairy projections on peripheral blood neoplastic cells

  • Stains

    • positive: CD11c, CD25, CD103, CD20, CD22, TRAP+, Annexin A1, BRAF

  • Molecular

    • BRAF V600E
    		•