DLBCL Hodgkin lymphoma


Expand All | Collapse All

  • Names

    • Grey zone lymphoma

  • Clinical

    • young men, 20-40
    • site: large anterior mediastinal mass +/- supraclavicular node

  • Morphology

    • architecture: sheet like, fibrotic stroma
    • cytology: pleomorphic, Reed-Sternberg like
    • can have scattered eos, lymphs, histiocytes
    • can have necrosis without PMNs

  • Immunophenotype

    • classical Hodgkin: CD15+, CD30+
    • DLBCL: CD20+, CD45+
    • other positives: PAX5, OCT2, BOB1
    • background lymphs: predominantly CD4+

  • Specific patterns

    • morphology of nodular sclerosis HL, but CD20+, CD15-
    • morphology of mediastinal large B lymphoma, but CD20-, CD15+ or EBV+
    		•