Carcinoid


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  • Clinical

    • lung
      • atypical carcinoid more commonly peripheral
      • carcinoid syndrome only when widespread metastasis
    • prostate: rare

  • Histology

    • nests (organoid) or cords (trabecular)
    • other patterns
      • spindle cell
      • papillary
      • pseudoglandular
      • follicular
    • rosettes
    • cytology
      • scant-moderate cytoplasm
      • oncocytic type can have abundant cytoplasm

  • Types

    • typical carcinoid
    • atypical carcinoid

  • Stains

    • CK+
    • chromogranin, synaptophysin, CD56+

  • Ddx

    • large cell neuroendocrine tumor
      • more mitosis
      • necrosis
    • small cell carcinoma
      • more mitosis
      • necrosis
    • paraganglioma
      • CK-
    • other ddx is negative for neuroendocrine marker
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