CNS DLBCL


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  • Clinical

    • < 1% non-Hodgkins
    • 2-3% of brain tumors
    • median age 60
    • site:
  • Morphology

    • architecture: perivascular, diffuse/solid in denser areas
    • cytology: resembles centroblasts
  • Stains

    • B markers+
    • Mum1 (90%, strong)
    • BCL6 (60-80%)
    • BCL2 (frequent)
    • CD10 (10-20%)