AIS


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  • Clinical

    • 50% also have CIN

  • Histology

    • no invasion: neoplastic glands are no deeper than normal ones
    • architecture: stratification, cribriforming
    • cytology: hyperchromasia, elongated, mitosis

  • Ddx

    • glandular dysplasia
      • falls short of adenocarcinoma in situ
    • glandular atypia
      • reactive inflammation changes
    		•